Effects of different types of sleep disorders on quality of life in patients with Parkinson's disease

Upload time:2017-02-27 Browse:

Author: Zhang Hong Zhang Yong Lu Zuneng Dong Hongjuan Huang Tingting Luo can
Abstract: Objective To analyze the effect of different types of sleep disorders on the quality of life in patients with Parkinson's disease (PD), and to provide evidence for clinical intervention. Methods the quality of life of 92 patients with PD was assessed by using the Chinese version of the Parkinson disease quality of life questionnaire (PDQ-39). Using the Epworth sleepiness score, Hongkong version of the REM sleep behavior disorder questionnaire (RBDQ-HK), PD non motor symptoms questionnaire (NMSQuest) of fourth and sixth, Pittsburgh sleep quality index scale in tenth were assessed with excessive daytime sleepiness (EDS), REM sleep behavior disorder (RBD), insomnia, restless leg syndrome (RLS), sleep apnea (SDB) etc.. To analyze the effect of different types of sleep disorders on quality of life in patients with PD. Results the PDQ-39 score of PD patients with sleep disorders was significantly higher than that of PD patients without sleep disorder (P<0.05). In all kinds of sleep disorders, insomnia as predictors of quality of life in patients with PD (R2=0.138, P=0.000) the strongest, followed by RLS (R2=0.040, P=0.000), H-Y was also predicted, the 3 affect the total score of PDQ-39 was to determine the role of the 52%. The effects of RBD, EDS and SDB on the quality of life of patients with PD were not obvious. Conclusion sleep disorders can significantly reduce the quality of life in patients with PD, of which the most significant impact of insomnia, RLS.
Key words: Parkinson's disease; quality of life; insomnia; restless legs syndrome
Influence of sleep disorders on health-related quality of life in the patients with Parkinson s disease ZHANG Hong* ", ZHANG Yong, LU Zuneng, LUO Can, HUANG Tingting. *Department of Neurology, Renmin Hospital of Wuhan University Wuhan, 430060, China
Corresponding author: LU Zuneng, Email: lzn196480@126.com
ABSTRACT: Objective To explore the influence of sleep disorders on health-related quality of life (HRQOL) in the patients with Parkinson s disease (PD). Methods PD patients were assessed 92 consecutive for HRQOL by 39-item Parkinson 's Disease Questionnaire (PDQ-39). Excessive daytime sleepiness (EDS), rapid eye movement sleep behavior disease (RBD insomnia, restless), legs syndrome (RLS) and sleep-disordered breathing (SDB) were evaluated via Epworth Sleep Scale (ESS), REM Sleep Behavior Disorder Questionnair (RBDQ-HK), the question 4 and question 6 of PD NMS Questionnaire and the question the Pittsburgh Sleep Quality 10 in Index. Stepwise multiple linear regression analysis was used to investigate the influence of different sleep dis Orders on the patient s HRQOL. Results The PDQ-39 "score was significantly higher in PD patients with sleep disorders than patients without sleep disorders. The major influencing factors of low HRQOL were insomnia (R2=0.138, P=0.000) and RLS (R2= 0.04, P=0.008). The predominant predictors in this study explained of the variation of the 52% PDQ-39 summary index score, but, RBD, EDS, and SDB were not the significant predictors of HRQOL. Conclusions Sleep disorders are associated with low HRQOL, insomnia may be the strongest independent predictor of low HRQOL, RLS comes second.
Key words: Parkinson's quality; Health-related of life; insomnia; restless legs syndrome; disease
Parkinson's disease (Parkinson disease PD) is a common neurodegenerative disease, not only affects the dopamine system in substantia nigra, 5- can also affect serotonin nerve system, noradrenergic system, cholinergic system, resulting in sleep disorders. The incidence of 60%~98%[1] between sleep disorders, including insomnia, sleep apnea (sleep-disordered breathing, SDB), rapid eye movement sleep behavior disorder (REM sleep behavior disorder, RBD), excessive daytime sleepiness (Excessive Daytime, Sleepiness, EDS), restless legs syndrome (Restless Legs, Syndrome, RLS). Previous PD treatment focused on improving the patient's motor symptoms, but not enough attention to the treatment of sleep disorders. A number of studies have found that sleep disorders can significantly reduce the quality of life of patients, but which type has the greatest impact, has not yet been retrieved related research. The purpose of this study was to explore the effect of sleep disorder on the quality of life in patients with PD, so as to guide the clinical use of PD in patients with PD and improve the ability of daily living.
1 objects and methods
1.1 selected 2014-02 - 2016-05 patients in the Department of Neurology, people's Hospital of Wuhan University from to 92. Inclusion criteria: meet the clinical diagnostic criteria for [2] PD 1992 British bank primary PD; above patients were educated in primary school, can independently complete the questionnaire; suffering from severe liver and kidney disease, mental disorders and dementia were excluded. All patients signed informed consent.
1.2 method
1.2.1 data collection: the face of the patients were evaluated by the neurology specialist, the nervous system examination. The survey included gender, age, course of disease and education. All scales were evaluated in patients in the "open" period to complete a one-time.
The severity of 1.2.2 was assessed using Hoehn&Yahr (H-Y) to assess the severity of the patients, divided into mild (1, grade 1.5 and grade 2), moderate (grade 2.5 and grade 3), and severe (grade 4 and grade 2).
1.2.3 evaluation of sleep disorders by REM sleep behavior disorder questionnaire - Hongkong (REM Sleep Behavior Disorder Questionnair version, RBDQ-HK) screening of RBD, score of RBDQ-HK were higher than 17 points that there is RBD[3]; using Epworth sleepiness scale